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19th Ave New York, NY 95822, USA

Saturday, June 24, 2023

01:00pm – 06:00pm

Registration

Culture Keepers Registration

02:00pm – 05:30pm

APS Council Meeting

Powell Boardroom

03:30pm – 05:00pm

Workshop on Career Development

Join us in career development workshop to learn how to navigate your future career by using three key elements: Explore, Connect, Develop.

Panelists:
Rumit Maini, Director, Business Development PepLib
Shauna Clark, Senior Diversity Advisor, National Cancer Institute
Heba Salim, Advisor, Eli Lilly and Company
Victor Outlaw, Assistant Professor, University of Missouri
George Burslem, Assistant Professor, University of Pennsylvania
Nat Goldberg, Scientist, Aralez Bio

Cushing

06:00pm – 06:10pm

PRESIDENT’S WELCOME

Joel Schneider, National Cancer Institute, Center for Cancer Research

Kierland Ballroom 3 & 4

06:10pm – 07:00pm

OPENING PLENARY KEYNOTE LECTURE

Introduction: Paramjit Arora

L01Laura L. Kiessling, Massachusetts Institute of Technology
Peptide-Glycan Interactions in Immunity

Kierland Ballroom 3 & 4

07:00pm – 09:00pm

Opening Reception With Exhibitors

Kierland Ballroom 1 & 2

Sunday, June 25, 2023

08:00am – 04:30pm

Registration

Culture Keepers Registration

08:00am

Group 1 Poster Set Up

Hall of State

08:30am – 08:35am

Opening Remarks – APS 2023 Co-Chairs

Robert Garbaccio, Merck
David Chenoweth, University of Pennsylvania

Kierland Ballroom 3 & 4

08:35am – 10:25am

SESSION 1: PEPTIDE TOOLS & PROBES

Session Chair:
Anna Mapp, University of Michigan

Kierland Ballroom 3 & 4

08:35am – 09:00am

L02Christian Becker, University of Vienna
Zooming into Posttranslational Modifications by Protein Semisynthesis

 

09:00am – 09:25am

L03Ross Cheloha, National Institute of Health
Connecting Peptides and Antibodies to Probe Cell Surface Receptors

 

09:25am – 09:45am

L04Nicholas Sawyer, Fordham University
A Rational Crosslinking Approach for Peptide Polyproline II Helices

 

09:45am – 10:05am

L05Dennis Bong, The Ohio State University
Novel Fluorogenic Peptide Probes for Intracellular RNA and RNP Tracking

 

10:05am – 10:25am

L06Amelia Fuller, Santa Clara University
Aromatic Residue Placement Influences Helical Structure of Short Peptoid Oligomers in Aqueous Solutions

 

10:25am – 10:50am

Coffee with Exhibitors & Posters

Hall of State, Kierland 1 & 2

10:50am – 12:00pm

SESSION 2: PROTEIN MODIFICATIONS FOR ENABLING BIOLOGY

Session Chair:
James Checco, University of Nebraska-Lincoln

Kierland Ballroom 3 & 4

10:50am – 11:15am

L07Champak Chatterjee, University of Washington
SUMO: Wrestling with Gene Transcription

 

11:15am – 11:40am

L08Yael David, Memorial Sloan Kettering Cancer Center
Uncovering Cancer-Associated Epigenetic Events using Novel Chemical Tools

 

11:40am – 12:00pm

L09Mark Distefano, University of Minnesota
Protein Prenylation: New Tools Reveal New Biology

 

12:00pm – 12:15pm

DR. ELIZABETH SCHRAM YI ORAL COMPETITION

 

 

L10 – YI1Zoë Adams, The Scripps Research Institute
Stretching Peptides: Diyne-Braced Peptides as Beta-Strand Mimics

 

12:15pm – 12:45pm

EARLY CAREER LECTURESHIP AWARD

Introduction:
Michael S. Kay, University of Utah School of Medicine

Kierland Ballroom 3 & 4

 

L11 – AWDanny Chou, Stanford University
Stimuli-Responsive Therapeutics through Peptide Chemistry

 

12:45pm – 02:15pm

Lunch with Exhibitors – Provided

Kierland Ballroom 1 & 2

02:15pm – 03:45pm

SESSION 3: NOVEL MODULATORS OF BIOLOGY

Session Chair:
Yftah Tal-Gan, University of Nevada, Reno

Kierland Ballroom 3 & 4

02:15pm – 02:40pm

L12Tom N. Grossmann, VU University Amsterdam
From Protein Structures to Functional Biomimetics

 

02:40pm – 03:05pm

L13Nir Qvit, Bar-Ilan University
Engineered Novel Protein-Protein Interaction Regulators to Study Mitochondrial Function and Modulate Mitochondrial Homeostasis

 

03:05pm – 03:25pm

L14Vita Sereikaite, University of Copenhagen
Towards Cognition Enhancing Therapeutics: Regiospecific Modulation of GABAB Receptors using Peptide-Based Inhibitors

 

03:25pm – 03:45pm

L15Eileen Kennedy, University of Georgia
Novel Allosteric Targeting Strategies to Inhibit LRRK2 in Parkinson’s Disease using Constrained Peptides

 

03:45pm – 04:00pm

DR. ELIZABETH SCHRAM YI ORAL COMPETITION

 

 

L16 – YI2Benjamin Emenike, Emory University
Chemical Tools for Profiling Lysine Dimethylation and N-Terminal Dimethylation of Proteins

 

04:00pm – 04:15pm

Afternoon Break

 

04:15pm – 05:25pm

MERRIFIELD AWARD LECTURE

Introduction:
James Checco, University of Nebraska-Lincoln

L17 – AWSam Gellman, University of Wisconsin at Madison
Merrifield’s Legacy: Transcending the Tyranny of the Ribosome

Kierland Ballroom 3 & 4

05:30pm – 06:30pm

Workshop: Great Minds Think Differently: Inspiring Equity & Inclusion

Dr. Shauna Clark, Scientific Diversity Advisor to the Director, Center for Cancer Research at NCI

Attendees will learn about and discuss topics related to diversity, equity, inclusivity and accessibility, DEIA. First, Dr. Clark will address challenges to creating diverse and equitable workplaces. Then, Dr. Clark will provide examples of strategies and programs implemented at NCI that can accelerate research by improving climate and enhancing DEIA. The session will also include time for facilitated discussion. In these discussions, we will work collaboratively to identify actionable strategies that will elevate the value of the American Peptide Society to a diverse membership.

Cushing

07:00pm – 09:00pm

Student Mixer

Culture Keeper’s Hall W

Monday, June 26, 2023

08:00am – 04:30pm

Registration

Culture Keepers Registration

08:30am – 10:20am

SESSION 4: PROTEIN ARCHITECTURES – STRUCTURE AND FUNCTION

Session Chair: Philip Dawson, Scripps Research Institute

Kierland Ballroom 3 & 4

08:30am – 08:55am

L18Ron Raines, Massachusetts Institute of Technology
A New Role for Methionine Residues

 

08:55am – 09:20am

L19Emma Watson, The University of Adelaide
New Selenium-Mediated Methods for Protein Synthesis and Modification

 

09:20am – 09:40am

L20Brett VanVeller, Iowa State University
Thioimidates: An Obscure Functional Group Provides General Access to Peptide Bond Isosteres

 

09:40am – 10:00am

L21Marina Rubini, University College of Dublin
4-Thiaproline Eliminates the Slow Folding Phase of Proteins With Cis Prolines in The Native State

 

10:00am – 10:20am

L22Jianfeng Cai, University of South Florida
Sulfonyl-γ-AApeptides: Structure and Function

 

10:20am – 10:45am

Coffee with Exhibitors & Posters

Hall of State, Kierland 1 & 2

10:45am – 12:15pm

SESSION 5: PEPTIDE MATERIALS AND DELIVERY

Session Chair: Stephen Miller, Genentech

Kierland Ballroom 3 & 4

10:45am – 11:10am

L23Christopher Alabi, Cornell University
PROteolysis TArgeting Chimeras – PROTACs

 

11:10am – 11:35am

L24Scott Medina, Penn State College of Engineering
Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions

 

11:35am – 11:55am

L25Giovanna Ghirlanda, Arizona State University
Membraneless Organelles by Design: The Carboxysome

 

11:55am – 12:15pm

L26Shiroh Futaki, Kyoto University
Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides

 

12:15pm – 12:45pm

MAKINENI LECTURE

Introduction: Anna Mapp, University of Michigan

Kierland Ballroom 3 & 4

 

L27 – AWCésar de la Fuente, University of Pennsylvania
AI for Antibiotic Discovery

 

12:45pm – 02:30pm

Lunch with Exhibitors – Provided

Kierland Ballroom 1 & 2

01:00pm – 02:00pm

International Liaison Meeting

Powell Boardroom

02:30pm – 04:00pm

SESSION 6: PEPTIDE DRUG DISCOVERY

Session Chair: Ved Srivastava, Perpetual Medicines

Kierland Ballroom 3 & 4

02:30pm – 02:55pm

L28Ruchia Duggal, Merck
DMPK Optimization of Macrocyclic Peptides: Targeting Intra vs. Extracellular Sites

 

02:55pm – 03:20pm

L29Miguel Castanho, University of Lisbon
Developing Broad Spectrum Brain-Targeting Peptide-Drug Conjugates Against Flaviviruses and Other Envelope Viruses

 

03:20pm – 03:40pm

L30Hongchang Qu, Eli Lilly
The Novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943: From Discovery to Clinical Proof-of-Concept

 

03:40pm – 04:00pm

L31Florence Brunel, Novo Nordisk
A High Potency Protein that Normalizes Body Weight in DIO Mice through Triple Agonism at the FGF21, Glp-1 and GIP Receptors

 

04:00pm – 04:30pm

DR. ELIZABETH SCHRAM YI ORAL COMPETITION

 

04:00pm – 04:15pm

L32 – YI3Carly Schissel, University of California, Berkeley
In-Cell Penetration Selection — Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery

 

04:15pm – 04:30pm

L33 – YI4Sheryl Sharma, University of Nebraska at Lincoln
Identifying Peptide-Receptor Interactions using Aryl Diazonium-Labeled Peptide Ligands

 

04:30pm – 04:45pm

Afternoon Break

 

04:45pm – 05:25pm

POSTER FLASH TALKS

Kierland Ballroom 3 & 4

05:25pm – 05:55pm

GOODMAN LECTURE

Introduction: Joel Schneider, National Cancer Institute – Center for Cancer Research

Kierland Ballroom 3 & 4

 

L34 – AWJames P. Tam, Nanyang Technological University
Finding from Nature a New Paradigm for Orally-Active and Cell-penetrating Bioactive Microproteins

 

06:00pm – 08:00pm

GROUP 1 POSTER SESSION & RECEPTION

Hall of State, Kierland 1 & 2

Tuesday, June 27, 2023

08:00am – 12:30pm

Registration

Culture Keepers Registration

08:30am – 10:25am

SESSION 7: FROM NATURAL PRODUCTS TO UNNATURAL BIOACTIVE PEPTIDES

Session Chair: Robin Polt, University of Arizona

Kierland Ballroom 3 & 4

08:30am – 08:55am

L35Dale L. Boger, The Scripps Research Institute
Maxamycins: Redesigned Vancomycins for Resistant Bacteria

 

08:55am – 09:20am

L36Andrew Roberts, University of Utah
Tyrosine-Selective Peptide Cyclization Methods Inspired by Cyclic Peptide Natural Products

 

09:20am – 09:40am

L37Christoph Nitsche, Australian National University
Biocompatible Peptide Cyclisation and Protein Modification

 

09:40am – 10:00am

L38Christina Schroeder, Genentech
Recifin A, a Novel and Selective Allosteric Inhibitor of Tyrosyl- DNA Phosphodiesterase I with a Unique Disulfide-bond Topology

 

10:00am – 10:25am

L39Andrei Yudin, University of Toronto
Development of Privileged Macrocyclic Motifs Using the Tools of Chemical Synthesis

 

10:25am – 10:50am

Coffee with Exhibitors & Posters

Hall of State, Kierland 1 & 2

10:50am – 11:20am

DR. ELIZABETH SCHRAM YI ORAL COMPETITION

 

10:50am – 11:05am

L40 – YI5Simon Rössler, Massachusetts Institute of Technology
Abiotic Peptides for the Encoding of Small Molecule Synthesis

 

11:05am – 11:20am

L41 – YI6Estefania Martinez-Valdivia, University of Michigan
A Lipopeptidomimetic Transcriptional Inhibitor

 

11:20am – 12:50pm

SESSION 8: NATURAL PRODUCT BIOSYNTHESIS & INSPIRATION FROM NATURE

Session Chair: Stephanie Barros, Janssen R&D

Kierland Ballroom 3 & 4

11:20am – 11:45am

L42Wilfred A. van der Donk, University of Illinois at Urbana-Champaign
Biosynthesis and Engineering of Cyclic Peptide Natural Products

 

11:45am – 12:10am

L43Betsy Parkinson, Purdue University
Synthetic Natural Product Inspired Cyclic Peptides for Discovery of Bioactive Natural Products and Biocatalysts

 

12:10am – 12:30pm

L44Ines Neundorf, University of Cologne
Peptides Interfering With TANGO1 Reduce Collagen Secretion and Prevent Skin Fibrosis

 

12:30pm – 12:50pm

L45Arundhati Nag, Carlson School of Chemistry and Biochemistry, Clark University
Use of Proximity-Catalyzed IEDDA Reaction for Cyclic Library Screening to Target Point-Mutant Protein

 

12:50pm

Lunch on your own

 

01:00pm – 02:30pm

Dr. Elizabeth Schram Young Scientists’ Lunch & Mixer
Invited Graduate students & Post-Docs only

Deseo

01:00pm – 02:30pm

Exhibitor Workshop, hosted by Biotage

Streamlining Hit-to-Lead Optimization: Automating Highly Parallel Peptide Synthesis and Purification

Come join us for lunch and meet our scientific team to learn about new technologies enabling high throughput peptide library production – reducing the time required to deliver compounds for secondary assay evaluation!

Cushing

Wednesday, June 28, 2023

08:00am – 4:00pm

Registration

Culture Keepers Registration

08:55am – 10:25am

SESSION 9: PEPTIDE SYNTHETIC METHODS & GREEN CHEMISTRY APPROACHES

Session Chair: Krishna Kumar, Tufts University

Kierland Ballroom 3 & 4

08:55am – 09:20am

L47Jenn Stockdill, Wayne State University
Waste Not, Want Not: Innovations in Complex Peptide Synthesis Fueled by a Focus on Green Chemistry

 

09:20am – 09:40am

L48Nicholas Mitchell, University of Nottingham
A Radical Approach to the Site-Selective Modification of Peptides and Proteins

 

09:40am – 10:00am

L49Beatriz Garcia De La Torre, University of KwaZulu-Natal
Refractive Index: A Process Analytical Tool for Real-Time Monitoring of SPPS. Beyond a Qualitative Application

 

10:00am – 10:25am

L50Nina Hartrampf, University of Zurich
A Versatile “Synthesis Tag” for Chemical Protein Synthesis

 

10:25am – 10:50am

Coffee with Exhibitors & Posters

Hall of State, Kierland 1 & 2

10:50am – 11:05am

DR. ELIZABETH SCHRAM YI ORAL COMPETITION

 

10:50am – 11:05am

L51 – YI7Troy Smith, University of Arizona
Minimally Competent Lewis Acids: Effective and Efficient Catalysts for β-Glycosylation of Peptide Hormones

 

11:05am – 12:15pm

SESSION 10: BIOINSPIRED & INTELLIGENT PEPTIDE MATERIALS

Session Chair: Ana Salome Veiga, Instituto de Medicina Molecular

Kierland Ballroom 3 & 4

11:05am – 11:30am

L52Matthew Tirrell, University of Chicago, Pritzker School of Molecular Engineering
Peptide-Conjugated Polyelectrolyte Complex Micelles

 

11:30am – 11:55am

L53Abigail Knight, University of North Carolina at Chapel Hill
Self-Assembly of Peptide-Polymer Hybrid Materials

 

11:55am – 12:15pm

L54Paula Gomes, University of Porto
“Clicking” Peptides to Biomaterials and to Ionic Liquids: Towards Dual-Action Topical Formulations for Skin and Soft Tissue Infections

 

12:15pm – 12:45pm

DU VIGNEAUD LECTURE

Introduction: Ron Raines, Massachusetts Institute of Technology

Kierland Ballroom 3 & 4

 

L55 – AWHelma Wennemers, ETH Zurich
Synthetic Collagen Peptides – From Structure to Function

 

12:45pm – 02:30pm

Lunch on your own

 

12:45pm – 02:15pm

Vincent du Vigneaud Award Lunch, by invitation

Tribal

02:30pm – 02:45pm

APS GENERAL ASSEMBLY

Kierland Ballroom 3 & 4

02:45pm – 04:15pm

SESSION 11: PEPTIDE DESIGN AND FUNCTION

Session Chair: Elisabetta Bianchi, IRBM

Kierland Ballroom 3 & 4

02:45pm – 03:10pm

L56Sidney M. Hecht, Arizona State University/ Biodesign Institute
Ribosomal Synthesis of Peptides and Proteins Containing Non-Canonical Amino Acids

 

03:10pm – 03:35pm

L57Maria Soloveychik, SyntheX
Cell-Based Function Selection of Peptides for Protein-Protein Interaction Disruption and Targeted Protein Degradation

 

03:35pm – 03:55pm

L58Thomas Tucker, Merck Research Laboratories
Cyclic Peptide PCSK9 Inhibitors : The Design and Optimization of Highly Potent, Orally Bioavailable, and Clinically Viable Molecules as LDL-Cholesterol Lowering Therapeutics

 

03:55pm – 04:15pm

L59Ping Ye, UCB
Discovery of Zilucoplan: A Potent Macrocyclic Peptide Complement Component 5, C5, Inhibitor in Acetylcholine Receptor Antibody-positive Generalized Myasthenia Gravis

 

04:15pm – 04:30pm

DR. ELIZABETH SCHRAM YI ORAL COMPETITION

 

 

L60 – YI8Alexander Lund Nielsen, Ecole Polytechnique Fédérale de Lausanne
Assessing the Cellular Permeability of Peptidic Macrocycles in High-Throughput

 

04:30pm – 04:45pm

Afternoon Break

 

04:45pm – 05:25pm

POSTER FLASH TALKS

Kierland Ballroom 3 & 4

05:25pm – 05:55pm

DU VIGNEAUD LECTURE

Introduction: Mark Distefano, University of Minnesota

Kierland Ballroom 3 & 4

 

L61 – AWMarcey Waters, University of North Carolina at Chapel Hill
How Do Post-Translational Modifications Turn on Protein-Peptide Interactions and how can We Inhibit Them?

 

06:00pm – 08:00pm

GROUP 2 POSTER SESSION & RECEPTION

Hall of State, Kierland 1 & 2

Thursday, June 29, 2023

08:00am – 10:30am

Registration

Culture Keepers Registration

08:30am – 10:05am

SESSION 12: NEW FRONTIERS IN COMPUTATIONAL PEPTIDE DESIGN PART 1

Session Chair: E. James Petersson, University of Pennsylvania

Kierland Ballroom 3 & 4

08:30am – 08:55am

L62William “Bill” DeGrado, University of California at San Francisco
De Novo Protein Design of Functional Proteins

 

08:55am – 09:15am

L63Fei Cai, Genentech
Improved Naive Peptide Library Designs Guided by AI-prediction

 

09:15am – 09:40am

L64John Jumper, DeepMind
Understanding Peptides and Their Interactions via Deep Learning Structure Prediction

 

09:40am – 10:05am

L65Carol K. Hall, North Carolina State University at Raleigh
Computational Design of Peptides as Detectors, Sensors, and Drugs

 

10:05am – 10:25am

Coffee Break

Hall of State

10:25am – 11:30am

SESSION 13: NEW FRONTIERS IN COMPUTATIONAL PEPTIDE DESIGN PART 2

Session Chair: Rumit Maini, PepLib

Kierland Ballroom 3 & 4

10:25am – 10:50am

L66Karen Akinsanya, Schrödinger
Computational Peptide Design Advances: Past, Present, and Future

 

10:50am – 11:10am

L67Joshua Price, Brigham Young University
Peptide/Protein Redesign Using Fine-Tuned ProtBert Masked Language Models

 

11:10am – 11:30am

L68Gaurav Bhardwaj, University of Washington, Seattle
Machine Learning Guided Structure Prediction and Design of Macrocycles

 

11:30am – 12:00pm

EARLY CAREER LECTURESHIP AWARD

Introduction: Philip Dawson, Scripps Research Institute

Kierland Ballroom 3 & 4

 

L69 – AWLara Malins, Research School of Chemistry at the Australian National University
Dialing in the Potential: Tunable Electrochemical Peptide Modifications

 

12:00pm – 02:00pm

Lunch on your own

 

02:00pm – 03:05pm

SESSION 14: NOVEL ADVANCES IN PEPTIDE CHEMISTRY

Session Chair: Anna Maria Papini, University of Florence

Kierland Ballroom 3 & 4

02:00pm – 02:25pm

L70Michael S. Kay, University of Utah School of Medicine
D-Peptide Therapeutics

 

02:25pm – 02:45pm

L71Seino Jongkees, Vrije Universiteit Amsterdam
Antiviral Peptides from mRNA Display Antiviral Peptides from mRNA Display

 

02:45pm – 03:05pm

L72Bobo Dang, Westlake University, China
Copper-Assisted Sequence-Specific Chemical Protein Conjugation

 

03:05pm – 03:20pm

Afternoon Break

 

03:20pm – 04:25pm

SESSION 15: INNOVATIVE METHODS FOR PEPTIDE STRUCTURE

Session Chair: Wendy Hartsock, Aralez Bio

Kierland Ballroom 3 & 4

03:20pm – 03:45pm

L73Jose Rodriguez, University of California at Los Angeles
Solving Peptide Structures and More: Frontier Advances in Electron Diffraction

 

03:45pm – 04:05pm

L74George Burslem, University of Pennsylvania
Beta-Peptides as Conditional Ligands for Peptide Exchange in MHC-I

 

04:05pm – 04:25pm

L75Matthew Tucker, University of Nevada at Reno
Mapping Structure and Dynamics with Site-Specific Vibrational Probe Pairs via 2D IR Spectroscopy

 

04:25pm – 05:15pm

CLOSING PLENARY KEYNOTE LECTURE

Introduction: William, “Bill” DeGrado, University of California, San Francisco

 

 

L76Jim Wells, University of California at San Francisco
Pirating Biology to Probe and Modulate the cell Surfaceome

 

05:15pm – 05:20pm

CLOSING REMARKS

Kierland Ballroom 3 & 4

07:00pm – 10:00pm

CLOSING BANQUET

Kierland Ballroom 1 & 2