Saturday, June 24, 2023
01:00pm – 06:00pm
Registration
Culture Keepers Registration
02:00pm – 05:30pm
APS Council Meeting
Powell Boardroom
03:30pm – 05:00pm
Workshop on Career Development
Join us in career development workshop to learn how to navigate your future career by using three key elements: Explore, Connect, Develop.
Panelists:
Rumit Maini, Director, Business Development PepLib
Shauna Clark, Senior Diversity Advisor, National Cancer Institute
Heba Salim, Advisor, Eli Lilly and Company
Victor Outlaw, Assistant Professor, University of Missouri
George Burslem, Assistant Professor, University of Pennsylvania
Nat Goldberg, Scientist, Aralez Bio
Cushing
06:00pm – 06:10pm
PRESIDENT’S WELCOME
Joel Schneider, National Cancer Institute, Center for Cancer Research
Kierland Ballroom 3 & 4
06:10pm – 07:00pm
OPENING PLENARY KEYNOTE LECTURE
Introduction: Paramjit Arora
L01 – Laura L. Kiessling, Massachusetts Institute of Technology
Peptide-Glycan Interactions in Immunity
Kierland Ballroom 3 & 4
07:00pm – 09:00pm
Opening Reception With Exhibitors
Kierland Ballroom 1 & 2
Sunday, June 25, 2023
08:00am – 04:30pm
Registration
Culture Keepers Registration
08:00am
Group 1 Poster Set Up
Hall of State
08:30am – 08:35am
Opening Remarks – APS 2023 Co-Chairs
Robert Garbaccio, Merck
David Chenoweth, University of Pennsylvania
Kierland Ballroom 3 & 4
08:35am – 10:25am
SESSION 1: PEPTIDE TOOLS & PROBES
Session Chair:
Anna Mapp, University of Michigan
Kierland Ballroom 3 & 4
08:35am – 09:00am
L02 – Christian Becker, University of Vienna
Zooming into Posttranslational Modifications by Protein Semisynthesis
09:00am – 09:25am
L03 – Ross Cheloha, National Institute of Health
Connecting Peptides and Antibodies to Probe Cell Surface Receptors
09:25am – 09:45am
L04 – Nicholas Sawyer, Fordham University
A Rational Crosslinking Approach for Peptide Polyproline II Helices
09:45am – 10:05am
L05 – Dennis Bong, The Ohio State University
Novel Fluorogenic Peptide Probes for Intracellular RNA and RNP Tracking
10:05am – 10:25am
L06 – Amelia Fuller, Santa Clara University
Aromatic Residue Placement Influences Helical Structure of Short Peptoid Oligomers in Aqueous Solutions
10:25am – 10:50am
Coffee with Exhibitors & Posters
Hall of State, Kierland 1 & 2
10:50am – 12:00pm
SESSION 2: PROTEIN MODIFICATIONS FOR ENABLING BIOLOGY
Session Chair:
James Checco, University of Nebraska-Lincoln
Kierland Ballroom 3 & 4
10:50am – 11:15am
L07 – Champak Chatterjee, University of Washington
SUMO: Wrestling with Gene Transcription
11:15am – 11:40am
L08 – Yael David, Memorial Sloan Kettering Cancer Center
Uncovering Cancer-Associated Epigenetic Events using Novel Chemical Tools
11:40am – 12:00pm
L09 – Mark Distefano, University of Minnesota
Protein Prenylation: New Tools Reveal New Biology
12:00pm – 12:15pm
DR. ELIZABETH SCHRAM YI ORAL COMPETITION
L10 – YI1 – Zoë Adams, The Scripps Research Institute
Stretching Peptides: Diyne-Braced Peptides as Beta-Strand Mimics
12:15pm – 12:45pm
EARLY CAREER LECTURESHIP AWARD
Introduction:
Michael S. Kay, University of Utah School of Medicine
Kierland Ballroom 3 & 4
L11 – AW – Danny Chou, Stanford University
Stimuli-Responsive Therapeutics through Peptide Chemistry
12:45pm – 02:15pm
Lunch with Exhibitors – Provided
Kierland Ballroom 1 & 2
02:15pm – 03:45pm
SESSION 3: NOVEL MODULATORS OF BIOLOGY
Session Chair:
Yftah Tal-Gan, University of Nevada, Reno
Kierland Ballroom 3 & 4
02:15pm – 02:40pm
L12 – Tom N. Grossmann, VU University Amsterdam
From Protein Structures to Functional Biomimetics
02:40pm – 03:05pm
L13 – Nir Qvit, Bar-Ilan University
Engineered Novel Protein-Protein Interaction Regulators to Study Mitochondrial Function and Modulate Mitochondrial Homeostasis
03:05pm – 03:25pm
L14 – Vita Sereikaite, University of Copenhagen
Towards Cognition Enhancing Therapeutics: Regiospecific Modulation of GABAB Receptors using Peptide-Based Inhibitors
03:25pm – 03:45pm
L15 – Eileen Kennedy, University of Georgia
Novel Allosteric Targeting Strategies to Inhibit LRRK2 in Parkinson’s Disease using Constrained Peptides
03:45pm – 04:00pm
DR. ELIZABETH SCHRAM YI ORAL COMPETITION
L16 – YI2 – Benjamin Emenike, Emory University
Chemical Tools for Profiling Lysine Dimethylation and N-Terminal Dimethylation of Proteins
04:00pm – 04:15pm
Afternoon Break
04:15pm – 05:25pm
MERRIFIELD AWARD LECTURE
Introduction:
James Checco, University of Nebraska-Lincoln
L17 – AW – Sam Gellman, University of Wisconsin at Madison
Merrifield’s Legacy: Transcending the Tyranny of the Ribosome
Kierland Ballroom 3 & 4
05:30pm – 06:30pm
Workshop: Great Minds Think Differently: Inspiring Equity & Inclusion
Dr. Shauna Clark, Scientific Diversity Advisor to the Director, Center for Cancer Research at NCI
Attendees will learn about and discuss topics related to diversity, equity, inclusivity and accessibility, DEIA. First, Dr. Clark will address challenges to creating diverse and equitable workplaces. Then, Dr. Clark will provide examples of strategies and programs implemented at NCI that can accelerate research by improving climate and enhancing DEIA. The session will also include time for facilitated discussion. In these discussions, we will work collaboratively to identify actionable strategies that will elevate the value of the American Peptide Society to a diverse membership.
Cushing
07:00pm – 09:00pm
Student Mixer
Culture Keeper’s Hall W
Monday, June 26, 2023
08:00am – 04:30pm
Registration
Culture Keepers Registration
08:30am – 10:20am
SESSION 4: PROTEIN ARCHITECTURES – STRUCTURE AND FUNCTION
Session Chair: Philip Dawson, Scripps Research Institute
Kierland Ballroom 3 & 4
08:30am – 08:55am
L18 – Ron Raines, Massachusetts Institute of Technology
A New Role for Methionine Residues
08:55am – 09:20am
L19 – Emma Watson, The University of Adelaide
New Selenium-Mediated Methods for Protein Synthesis and Modification
09:20am – 09:40am
L20 – Brett VanVeller, Iowa State University
Thioimidates: An Obscure Functional Group Provides General Access to Peptide Bond Isosteres
09:40am – 10:00am
L21 – Marina Rubini, University College of Dublin
4-Thiaproline Eliminates the Slow Folding Phase of Proteins With Cis Prolines in The Native State
10:00am – 10:20am
L22 – Jianfeng Cai, University of South Florida
Sulfonyl-γ-AApeptides: Structure and Function
10:20am – 10:45am
Coffee with Exhibitors & Posters
Hall of State, Kierland 1 & 2
10:45am – 12:15pm
SESSION 5: PEPTIDE MATERIALS AND DELIVERY
Session Chair: Stephen Miller, Genentech
Kierland Ballroom 3 & 4
10:45am – 11:10am
L23 – Christopher Alabi, Cornell University
PROteolysis TArgeting Chimeras – PROTACs
11:10am – 11:35am
L24 – Scott Medina, Penn State College of Engineering
Real-Time, In Situ Imaging of Macrophages via Phase-Change Peptide Nanoemulsions
11:35am – 11:55am
L25 – Giovanna Ghirlanda, Arizona State University
Membraneless Organelles by Design: The Carboxysome
11:55am – 12:15pm
L26 – Shiroh Futaki, Kyoto University
Liquid Droplet Formation and Facile Cytosolic Translocation of IgG in the Presence of Attenuated Cationic Amphiphilic Lytic Peptides
12:15pm – 12:45pm
MAKINENI LECTURE
Introduction: Anna Mapp, University of Michigan
Kierland Ballroom 3 & 4
12:45pm – 02:30pm
Lunch with Exhibitors – Provided
Kierland Ballroom 1 & 2
01:00pm – 02:00pm
International Liaison Meeting
Powell Boardroom
02:30pm – 04:00pm
SESSION 6: PEPTIDE DRUG DISCOVERY
Session Chair: Ved Srivastava, Perpetual Medicines
Kierland Ballroom 3 & 4
02:30pm – 02:55pm
L28 – Ruchia Duggal, Merck
DMPK Optimization of Macrocyclic Peptides: Targeting Intra vs. Extracellular Sites
02:55pm – 03:20pm
L29 – Miguel Castanho, University of Lisbon
Developing Broad Spectrum Brain-Targeting Peptide-Drug Conjugates Against Flaviviruses and Other Envelope Viruses
03:20pm – 03:40pm
L30 – Hongchang Qu, Eli Lilly
The Novel GIP, GLP-1, and Glucagon Triple Receptor Agonist LY3437943: From Discovery to Clinical Proof-of-Concept
03:40pm – 04:00pm
L31 – Florence Brunel, Novo Nordisk
A High Potency Protein that Normalizes Body Weight in DIO Mice through Triple Agonism at the FGF21, Glp-1 and GIP Receptors
04:00pm – 04:30pm
DR. ELIZABETH SCHRAM YI ORAL COMPETITION
04:00pm – 04:15pm
L32 – YI3 – Carly Schissel, University of California, Berkeley
In-Cell Penetration Selection — Mass Spectrometry Produces Noncanonical Peptides for Antisense Delivery
04:15pm – 04:30pm
L33 – YI4 – Sheryl Sharma, University of Nebraska at Lincoln
Identifying Peptide-Receptor Interactions using Aryl Diazonium-Labeled Peptide Ligands
04:30pm – 04:45pm
Afternoon Break
04:45pm – 05:25pm
POSTER FLASH TALKS
Kierland Ballroom 3 & 4
05:25pm – 05:55pm
GOODMAN LECTURE
Introduction: Joel Schneider, National Cancer Institute – Center for Cancer Research
Kierland Ballroom 3 & 4
L34 – AW – James P. Tam, Nanyang Technological University
Finding from Nature a New Paradigm for Orally-Active and Cell-penetrating Bioactive Microproteins
06:00pm – 08:00pm
GROUP 1 POSTER SESSION & RECEPTION
Hall of State, Kierland 1 & 2
Tuesday, June 27, 2023
08:00am – 12:30pm
Registration
Culture Keepers Registration
08:30am – 10:25am
SESSION 7: FROM NATURAL PRODUCTS TO UNNATURAL BIOACTIVE PEPTIDES
Session Chair: Robin Polt, University of Arizona
Kierland Ballroom 3 & 4
08:30am – 08:55am
L35 – Dale L. Boger, The Scripps Research Institute
Maxamycins: Redesigned Vancomycins for Resistant Bacteria
08:55am – 09:20am
L36 – Andrew Roberts, University of Utah
Tyrosine-Selective Peptide Cyclization Methods Inspired by Cyclic Peptide Natural Products
09:20am – 09:40am
L37 – Christoph Nitsche, Australian National University
Biocompatible Peptide Cyclisation and Protein Modification
09:40am – 10:00am
L38 – Christina Schroeder, Genentech
Recifin A, a Novel and Selective Allosteric Inhibitor of Tyrosyl- DNA Phosphodiesterase I with a Unique Disulfide-bond Topology
10:00am – 10:25am
L39 – Andrei Yudin, University of Toronto
Development of Privileged Macrocyclic Motifs Using the Tools of Chemical Synthesis
10:25am – 10:50am
Coffee with Exhibitors & Posters
Hall of State, Kierland 1 & 2
10:50am – 11:20am
DR. ELIZABETH SCHRAM YI ORAL COMPETITION
10:50am – 11:05am
L40 – YI5 – Simon Rössler, Massachusetts Institute of Technology
Abiotic Peptides for the Encoding of Small Molecule Synthesis
11:05am – 11:20am
L41 – YI6 – Estefania Martinez-Valdivia, University of Michigan
A Lipopeptidomimetic Transcriptional Inhibitor
11:20am – 12:50pm
SESSION 8: NATURAL PRODUCT BIOSYNTHESIS & INSPIRATION FROM NATURE
Session Chair: Stephanie Barros, Janssen R&D
Kierland Ballroom 3 & 4
11:20am – 11:45am
L42 – Wilfred A. van der Donk, University of Illinois at Urbana-Champaign
Biosynthesis and Engineering of Cyclic Peptide Natural Products
11:45am – 12:10am
L43 – Betsy Parkinson, Purdue University
Synthetic Natural Product Inspired Cyclic Peptides for Discovery of Bioactive Natural Products and Biocatalysts
12:10am – 12:30pm
L44 – Ines Neundorf, University of Cologne
Peptides Interfering With TANGO1 Reduce Collagen Secretion and Prevent Skin Fibrosis
12:30pm – 12:50pm
L45 – Arundhati Nag, Carlson School of Chemistry and Biochemistry, Clark University
Use of Proximity-Catalyzed IEDDA Reaction for Cyclic Library Screening to Target Point-Mutant Protein
12:50pm
Lunch on your own
01:00pm – 02:30pm
Dr. Elizabeth Schram Young Scientists’ Lunch & Mixer
Invited Graduate students & Post-Docs only
Deseo
01:00pm – 02:30pm
Exhibitor Workshop, hosted by Biotage
Streamlining Hit-to-Lead Optimization: Automating Highly Parallel Peptide Synthesis and Purification
Come join us for lunch and meet our scientific team to learn about new technologies enabling high throughput peptide library production – reducing the time required to deliver compounds for secondary assay evaluation!
Cushing
Wednesday, June 28, 2023
08:00am – 4:00pm
Registration
Culture Keepers Registration
08:55am – 10:25am
SESSION 9: PEPTIDE SYNTHETIC METHODS & GREEN CHEMISTRY APPROACHES
Session Chair: Krishna Kumar, Tufts University
Kierland Ballroom 3 & 4
08:55am – 09:20am
L47 – Jenn Stockdill, Wayne State University
Waste Not, Want Not: Innovations in Complex Peptide Synthesis Fueled by a Focus on Green Chemistry
09:20am – 09:40am
L48 – Nicholas Mitchell, University of Nottingham
A Radical Approach to the Site-Selective Modification of Peptides and Proteins
09:40am – 10:00am
L49 – Beatriz Garcia De La Torre, University of KwaZulu-Natal
Refractive Index: A Process Analytical Tool for Real-Time Monitoring of SPPS. Beyond a Qualitative Application
10:00am – 10:25am
L50 – Nina Hartrampf, University of Zurich
A Versatile “Synthesis Tag” for Chemical Protein Synthesis
10:25am – 10:50am
Coffee with Exhibitors & Posters
Hall of State, Kierland 1 & 2
10:50am – 11:05am
DR. ELIZABETH SCHRAM YI ORAL COMPETITION
10:50am – 11:05am
L51 – YI7 – Troy Smith, University of Arizona
Minimally Competent Lewis Acids: Effective and Efficient Catalysts for β-Glycosylation of Peptide Hormones
11:05am – 12:15pm
SESSION 10: BIOINSPIRED & INTELLIGENT PEPTIDE MATERIALS
Session Chair: Ana Salome Veiga, Instituto de Medicina Molecular
Kierland Ballroom 3 & 4
11:05am – 11:30am
L52 – Matthew Tirrell, University of Chicago, Pritzker School of Molecular Engineering
Peptide-Conjugated Polyelectrolyte Complex Micelles
11:30am – 11:55am
L53 – Abigail Knight, University of North Carolina at Chapel Hill
Self-Assembly of Peptide-Polymer Hybrid Materials
11:55am – 12:15pm
L54 – Paula Gomes, University of Porto
“Clicking” Peptides to Biomaterials and to Ionic Liquids: Towards Dual-Action Topical Formulations for Skin and Soft Tissue Infections
12:15pm – 12:45pm
DU VIGNEAUD LECTURE
Introduction: Ron Raines, Massachusetts Institute of Technology
Kierland Ballroom 3 & 4
12:45pm – 02:30pm
Lunch on your own
12:45pm – 02:15pm
Vincent du Vigneaud Award Lunch, by invitation
Tribal
02:30pm – 02:45pm
APS GENERAL ASSEMBLY
Kierland Ballroom 3 & 4
02:45pm – 04:15pm
SESSION 11: PEPTIDE DESIGN AND FUNCTION
Session Chair: Elisabetta Bianchi, IRBM
Kierland Ballroom 3 & 4
02:45pm – 03:10pm
L56 – Sidney M. Hecht, Arizona State University/ Biodesign Institute
Ribosomal Synthesis of Peptides and Proteins Containing Non-Canonical Amino Acids
03:10pm – 03:35pm
L57 – Maria Soloveychik, SyntheX
Cell-Based Function Selection of Peptides for Protein-Protein Interaction Disruption and Targeted Protein Degradation
03:35pm – 03:55pm
L58 – Thomas Tucker, Merck Research Laboratories
Cyclic Peptide PCSK9 Inhibitors : The Design and Optimization of Highly Potent, Orally Bioavailable, and Clinically Viable Molecules as LDL-Cholesterol Lowering Therapeutics
03:55pm – 04:15pm
L59 – Ping Ye, UCB
Discovery of Zilucoplan: A Potent Macrocyclic Peptide Complement Component 5, C5, Inhibitor in Acetylcholine Receptor Antibody-positive Generalized Myasthenia Gravis
04:15pm – 04:30pm
DR. ELIZABETH SCHRAM YI ORAL COMPETITION
L60 – YI8 – Alexander Lund Nielsen, Ecole Polytechnique Fédérale de Lausanne
Assessing the Cellular Permeability of Peptidic Macrocycles in High-Throughput
04:30pm – 04:45pm
Afternoon Break
04:45pm – 05:25pm
POSTER FLASH TALKS
Kierland Ballroom 3 & 4
05:25pm – 05:55pm
DU VIGNEAUD LECTURE
Introduction: Mark Distefano, University of Minnesota
Kierland Ballroom 3 & 4
L61 – AW – Marcey Waters, University of North Carolina at Chapel Hill
How Do Post-Translational Modifications Turn on Protein-Peptide Interactions and how can We Inhibit Them?
06:00pm – 08:00pm
GROUP 2 POSTER SESSION & RECEPTION
Hall of State, Kierland 1 & 2
Thursday, June 29, 2023
08:00am – 10:30am
Registration
Culture Keepers Registration
08:30am – 10:05am
SESSION 12: NEW FRONTIERS IN COMPUTATIONAL PEPTIDE DESIGN PART 1
Session Chair: E. James Petersson, University of Pennsylvania
Kierland Ballroom 3 & 4
08:30am – 08:55am
L62 – William “Bill” DeGrado, University of California at San Francisco
De Novo Protein Design of Functional Proteins
08:55am – 09:15am
L63 – Fei Cai, Genentech
Improved Naive Peptide Library Designs Guided by AI-prediction
09:15am – 09:40am
L64 – John Jumper, DeepMind
Understanding Peptides and Their Interactions via Deep Learning Structure Prediction
09:40am – 10:05am
L65 – Carol K. Hall, North Carolina State University at Raleigh
Computational Design of Peptides as Detectors, Sensors, and Drugs
10:05am – 10:25am
Coffee Break
Hall of State
10:25am – 11:30am
SESSION 13: NEW FRONTIERS IN COMPUTATIONAL PEPTIDE DESIGN PART 2
Session Chair: Rumit Maini, PepLib
Kierland Ballroom 3 & 4
10:25am – 10:50am
L66 – Karen Akinsanya, Schrödinger
Computational Peptide Design Advances: Past, Present, and Future
10:50am – 11:10am
L67 – Joshua Price, Brigham Young University
Peptide/Protein Redesign Using Fine-Tuned ProtBert Masked Language Models
11:10am – 11:30am
L68 – Gaurav Bhardwaj, University of Washington, Seattle
Machine Learning Guided Structure Prediction and Design of Macrocycles
11:30am – 12:00pm
EARLY CAREER LECTURESHIP AWARD
Introduction: Philip Dawson, Scripps Research Institute
Kierland Ballroom 3 & 4
L69 – AW – Lara Malins, Research School of Chemistry at the Australian National University
Dialing in the Potential: Tunable Electrochemical Peptide Modifications
12:00pm – 02:00pm
Lunch on your own
02:00pm – 03:05pm
SESSION 14: NOVEL ADVANCES IN PEPTIDE CHEMISTRY
Session Chair: Anna Maria Papini, University of Florence
Kierland Ballroom 3 & 4
02:25pm – 02:45pm
L71 – Seino Jongkees, Vrije Universiteit Amsterdam
Antiviral Peptides from mRNA Display Antiviral Peptides from mRNA Display
02:45pm – 03:05pm
L72 – Bobo Dang, Westlake University, China
Copper-Assisted Sequence-Specific Chemical Protein Conjugation
03:05pm – 03:20pm
Afternoon Break
03:20pm – 04:25pm
SESSION 15: INNOVATIVE METHODS FOR PEPTIDE STRUCTURE
Session Chair: Wendy Hartsock, Aralez Bio
Kierland Ballroom 3 & 4
03:20pm – 03:45pm
L73 – Jose Rodriguez, University of California at Los Angeles
Solving Peptide Structures and More: Frontier Advances in Electron Diffraction
03:45pm – 04:05pm
L74 – George Burslem, University of Pennsylvania
Beta-Peptides as Conditional Ligands for Peptide Exchange in MHC-I
04:05pm – 04:25pm
L75 – Matthew Tucker, University of Nevada at Reno
Mapping Structure and Dynamics with Site-Specific Vibrational Probe Pairs via 2D IR Spectroscopy
04:25pm – 05:15pm
CLOSING PLENARY KEYNOTE LECTURE
Introduction: William, “Bill” DeGrado, University of California, San Francisco
L76 – Jim Wells, University of California at San Francisco
Pirating Biology to Probe and Modulate the cell Surfaceome
05:15pm – 05:20pm
CLOSING REMARKS
Kierland Ballroom 3 & 4
07:00pm – 10:00pm
CLOSING BANQUET
Kierland Ballroom 1 & 2